The data from our study show that MMX mesalamine 2.4 g/day or 4.8 g/day given once per day was well tolerated and efficacious for the induction of clinical and endoscopic remission of active, mild-to-moderate UC. The usual dosage of Mesalamine Rectal Suspension Enema in 60 mL units is one rectal instillation (4 grams) once a day, preferably at bedtime, and retained for approximately eight hours. While the effect of Mesalamine Rectal Suspension Enema may be seen within 3 to 21 days, the usual course of therapy would be from 3 to 6 weeks depending on symptoms and sigmoidoscopic findings. Studies. Make maintaining remission your mission with APRISO How once-daily APRISO may help you stay in ulcerative colitis (UC) remission. APRISO is a type of medication called mesalamine, or 5-ASA, and is thought to work by reducing inflammation and irritation in the colon. Effect of Once- or Twice-Daily MMX Mesalamine (SPD476) for the Induction of Remission of Mild to Moderately Active Ulcerative Colitis GARY R. LICHTENSTEIN,* MICHAEL A. KAMM,‡ PRABHAKAR BODDU,§ NATALYA GUBERGRITS, ANDREW LYNE,¶ ECCO - European Crohn´s and Colitis Organisation. The European Crohn\'s and Colitis Organisation is a highly active non-profit association focusing on Inflammatory Bowel Diseases (IBD). 5-aminosalicylic acid (5-ASA) preparations (eg, mesalazine, mesalamine) are well-established preparations used in the management of inflammatory bowel disease. These drugs are most useful for the treatment of mild to moderate flares of ulcerative colitis and, especially, for maintenance of remission Background & Aims: SPD476 (MMX mesalamine), a novel, once-daily mesalamine formulation, uses MMX Multi Matrix System (MMX) technology to delay and extend delivery of active drug throughout the colon. Mesalamine Once Daily Is More Effective Than Twice Daily in Patients With Quiescent Ulcerative Colitis AXEL U. DIGNASS,* BERND BOKEMEYER,‡ HENNING ADAMEK,§ MICHAEL MROSS, LARS VINTER-JENSEN,¶ Mesalamine may also be used for purposes not listed in this medication guide. Important Information Stop using mesalamine and call your doctor at once if you have severe stomach pain, cramping, bloody diarrhea (may occur with fever, headache , and skin rash ). In patients with high relapse rate (as measured by at least four moderate to severe relapses in the preceding 2 years), the continuous use of topical mesalamine (4 g/day) with high oral dosage (3.2 g–4.8 g/day) significantly decreased the total number of recurrences by increasing the mucosal concentration (Cohen et al 2000).